Recent WHO guidance has recommended CRP (with a threshold of >5 mg/L) for TB screening among people living with HIV (PLHIV), with a meta-analysis demonstrating 90% sensitivity (95% confidence interval [95%CI] 78–96%) and 50% specificity (29–71%) among outpatients initiating anti-retroviral therapy (ART).4 The gene discussed is CRP; the disease is tuberculosis.