Interestingly, the expression of 34 out of the 43 proximal interactors linked to the spliceosome correlated with a significant impact on the overall survival of BC patients (Fig 5A, S14 Table), including SNRNP40 (cluster 1), SF3B2 (cluster 2), SF3B5 (cluster 3), and SNW1 (cluster 4). This evidence concerns the gene SF3B5 and breast cancer.