IL-8 is another cytokine that is secreted by TAMs in HCC; it has a role in tumor growth, survival, angiogenesis, as well as EMT via the JAK2/STAT3/Snail signaling pathway [105] and activation of CXC chemokine receptor, and CC chemokine ligand 2 [106]. Here, JAK2 is linked to hepatocellular carcinoma.