As expressed in Fig 5, T2DM markedly inactivated the canonical Wnt/β-catenin signaling pathway as indicated by a twofold rise in ApoE-4 content (A), a fall of nearly 63% of Wnt5a (B), 68% of pS9 GSK-3β (C) and a 73% of pS675 β-catenin (D). The gene discussed is APOE; the disease is type 2 diabetes mellitus.