When SIRT3 inhibitors such as dipeptidyl peptidase-4 (DPP-4), P2X7 purinoceptors (P2X7R) (Jamali-Raeufy et al. 2020), and miR-494-3p (Geng et al. 2018) are inhibited, PD and related clinical symptoms improve. The gene discussed is DPP4; the disease is Parkinson disease.