In addition, although the subjects in some studies did not have neurological diseases, exercise and CR were shown to inhibit OS (Andrianova et al. 2020; Donniacuo et al. 2019; Jang et al. 2012; Jiang et al. 2014; Liang et al. 2013; Shi et al. 2005; Tsukiyama et al. 2017), inhibit inflammation (Traba et al. 2017, 2015), and promote autophagy (Li et al. 2018) through SIRT3. Here, SIRT3 is linked to nervous system disorder.