The univariate analyses showed that MAFLD, age, DM, prediabetes, hypertension, overweight/obesity, waist circumference, BFP, hyperuricemia, hypertriglyceridemia, HDL-C, remnant cholesterol, CRP, FIB-4 score, and NFS were significantly associated with an increased risk of CKD (p < 0.05). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.