In addition, it is also possible that Gs/cAMP-mediated pro-angiogenic effects are mediated by the cAMP-activated Rap1 GTP exchange factor EPAC, which has been shown to promote endothelial responses during tumor angiogenesis (Chrzanowska-Wodnicka, 2017; Garg et al., 2017). The gene discussed is APC; the disease is neoplasm.