ADM and neoplasm: This is based on the ability of adrenomedullin to induce pro-angiogenic effects in endothelial cells in vitro (Kim et al., 2003; Martinez et al., 2002; Zhang et al., 2017) as well as on the observation that the expression levels of adrenomedullin in tumors correlate with tumor angiogenesis in vivo (Hague et al., 2000; Martinez et al., 2002; Oehler et al., 2002).