ADM and neoplasm: In mice with inducible endothelium-specific loss of adrenomedullin (Tek-CreERT2;Admflox/flox mice, herein referred to as EC-Adm-KO mice; Iring et al., 2019), both retinal angiogenesis as well as tumor angiogenesis and tumor growth were normal (Fig. 5, e and g; and Fig. S3 g).