CCL2 and neoplasm: Furthermore, Ccl2 expression in tumor ECs isolated from EC-Gαs-KO mice was higher compared to control mice (Fig. 6 h), and tumors from MMTV-PyMT mice crossed with EC-Gαs-KO animals also expressed significantly more Ccl2 compared to tumors without loss of endothelial Gαs (Fig. S4 b).