VEGFA and Familial prostate cancer: Another study has shown that the cAMP/PKA pathway can promote the release of VEGF (Garg et al., 2017) and, in prostate cancer endothelial cells, the Gs-coupled β2 adrenergic receptor has been shown to induce an angiogenic switch, which occurs through the alteration of endothelial cell metabolism by inhibiting endothelial oxidative phosphorylation (Zahalka et al., 2017).