ADM and neoplasm: Since endothelial cells when exposed to adrenomedullin in culture show typical angiogenic responses and, since overexpression of adrenomedullin in tumors or systemic application of adrenomedullin results in increased vascular and lymphatic angiogenesis (Iimuro et al., 2004; Karpinich et al., 2013; Martinez et al., 2002; Oehler et al., 2002; Zhang et al., 2017), adrenomedullin has been suggested to mediate tumor angiogenesis.