KRAS and cancer: From the Gene Signature Expression Analysis (GSEA) database of “Hallmark gene sets,” the most significant match was with the gene set “Epithelial-mesenchymal transition.” Other gene set matches of obvious relevance to cell biological processes of cancer included “Hypoxia,” “Apoptosis,” “K-ras signaling up-regulated,” and “Angiogenesis” (Fig. 7D).