From this common network, five proteins, encoded by the Mmu16 region homologous to Hsa21, appeared to have stronger effects, based on the betweenness centrality index (APP, SOD1, KCNJ6, SYNJ1, ITSN1), whereas others had less impact (ATP5O, BACE2, BRWD1, DYRK1A, DSCAM, HLCS, IL10RB, INFAR2, INFGR2, KCNE1, KCNE2, KCNJ15, MRPL39, MX2, OLIG2), supporting the multigenic dimension in DS models. Here, SYNJ1 is linked to Dravet syndrome.