Animal research has allowed the identification of several major driver genes linked to the clinical features found in people with DS, such as DYRK1A and CBS, and made possible the pre-clinical validation of therapies with several drug candidates (Duchon and Herault, 2016; Herault et al., 2017; Nakano-Kobayashi et al., 2017; Faundez et al., 2018; Neumann et al., 2018; Nguyen et al., 2018; Marechal et al., 2019). The gene discussed is DYRK1A; the disease is Dravet syndrome.