Furthermore, our network analyses in Ts66Yah and Ts65Dn support the role of the DS subnetworks linked to RHOA, SNARE proteins (VAMPs and Sec protein interactors), DYRK1A and NPY (Fig. S11), which are deeply intertwined, as previously identified in seven other DS mouse models (Duchon et al., 2021). Here, NPY is linked to Dravet syndrome.