Variants in sarcoglycans subunits, a group of DGC components encoded by SGCA (OMIM: 600119), SGCB (OMIM: 600900), SGCD (OMIM: 601411), SGCG (OMIM: 608896), SGCE (OMIM: 604149) and SGCZ (OMIM: 608113), can lead to different types of LGMD. Here, SGCA is linked to limb-girdle muscular dystrophy.