There are pro- and antiviral properties ascribed to PML NBs, but it is generally accepted that these bodies and some of the proteins they contain pose a barrier to productive infection by several viruses (Niu et al., 2017; Guion et al., 2019; Scherer and Stamminger, 2016; Hofmann et al., 2021; Gasparovic et al., 2009). Here, PML is linked to infection.