USP29 and colorectal carcinoma: Our results revealed that silencing USP29 diminished SW620 and HCT116 cell viability (p < 0.01, Figure 2C), and reduced the number of colonies and EdU-positive cells (p < 0.01, Figure 2D and 2E), suggesting that USP29 downregulation suppressed malignant proliferation of CRC cells.