The loss of total SST‐IR cells in the DG of Engrailed2‐knockout compared to wild‐type mice (Provenzano et al., 2020; Sgadò et al., 2013) is associated with fewer reciprocal social behaviors, lack of preference toward investigating novel objects during testing, impaired prepulse inhibition (a measure of sensorimotor gaiting often impaired in these neurodevelopmental disorders), and poorer motor learning on the rotarod (Brielmaier et al., 2012). This evidence concerns the gene SST and neurodevelopmental disorder.