In summary, we discussed that αPD‐L1 blocks the signal crosstalk between NSCLC cells and TAMs by inhibiting STAT3 phosphorylation of TAM/M2 in vitro and in vivo, thus slowing down the EMT process, stemness, migration, angiogenesis and lung metastasis of NSCLC cells in vitro. The gene discussed is STAT3; the disease is non-small cell lung carcinoma.