SERPINE1 and pulmonary arterial hypertension: We selected Nos3 and Sod2 promoters because products of these genes are implicated in the pathogenesis of pulmonary hypertension (14, 15) and Abra and Serpine1 promoters because proteins encoded by these genes are involved in vascular smooth muscle biology and thrombosis (16, 17) and we recently observed that expression of Serpine1 and Abra was altered in aortas from rats fed a high-fat diet (18).