DNMT1 and Hypertension: Our novel findings suggest that the loss-of-function Mediterranean G6PDS188F variant, which has 60% to 80% less activity in lungs (Fig. 1B) but not protein expression and develop less systemic hypertension (7), antagonize DNMT-catalyzed DNA methylation, and pathogenic gene expression and, in the process, potentially reduce RV pressure overload/PH in SU/Hx/Nx rats.