However, we consistently observed that FBXL14 overexpression, which enhanced RPA194 degradation, sensitized the A375 melanoma cells to loss of viability and growth by BMH-21 as measured by a decrease in the GI50 and a reduction in the number of surviving colonies upon BMH-21 treatment (Fig. 4, A–E). The gene discussed is POLR1A; the disease is melanoma.