Data collected in LDLR-deficient mice indicate that enhanced EL activity accounts for the lowering of plasma LDL-C levels upon ANGPTL3 inactivation (44, 45), leading to the proposition that EL mediates the LDL-lowering effect of ANGPTL3-inactivating antibodies in patients with homozygous familial hypercholesterolemia (78). The gene discussed is ANGPTL3; the disease is familial hypercholesterolemia.