Intriguingly, both murine ILC1ls in the PyMT model and human Lin-CD56+CD127-CD7+CD45RO+ cells in CRC are accompanied by a clear enrichment of CD8+ ILTKCs with high killing potential, pointing towards an overarching program of innate-like tumor cytotoxicity possibly governed by tumor-derived IL-15 and additional signals [31], [69], [78]. Here, IL15 is linked to colorectal carcinoma.