FCGR3A genotype was associated with rituximab-induced NK-cell degranulation in HC, RA and SLE, whereby FCGR3A-158V carriage and FCGR3A-158V homozygosity were associated with greater degranulation in HC (Mann–Whitney test; both p = 0.01; Fig. 4d), RA and SLE combined (Mann–Whitney test; p = 0.02, 0.05; Fig. 4e), respectively, compared to FCGR3A-138FF. The gene discussed is FCGR3A; the disease is systemic lupus erythematosus.