Using samples from treatment-naïve, early RA patients, we observed increased NK-cell CD32 expression with FCGR2C-ORF carriage (Mann–Whitney test; p < 0.0001) and in individuals hemizygous for the CNR1 deletion, which carries both FCGR2C and FCGR3B (Fig. 1b). This evidence concerns the gene FCGR3B and rheumatoid arthritis.