ACE and Rare hereditary thrombophilia: In particular, ACE D/D genotype was associated to thromboembolic manifestations in patients affected by other diseases with no pre-existing risk factors and traditional thrombophilia-related polymorphisms [22], increased venous thromboembolism risk in patients with a thrombogenic condition [23, 24], and hypercoagulability and endothelial damage in hypertensive patients [25].