More importantly, schistosome infection or sepsis also resulted in abnormal mTEC/cTEC compartments, as shown by an increased proportion of mTECs but a decreased proportion of cTECs, while IL-33 or ST2 deficiency, or anti-IL-33 treatment restored mTEC/cTEC compartments in mice with schistosomiasis (Fig. 5l–r, S6i–l) or sepsis (Fig. S6m–o). The gene discussed is IL1RL1; the disease is schistosomiasis.