Concomitant with restored thymic phenotype and function, the TCR avidity of naive T cells was markedly higher in Il-33−/− mice with schistosomiasis or sepsis than that in wildtype mice, as shown by a reduced decline in expression levels of CD5 on naive T cells in thymus, spleen, and blood in Il-33-/- mice (Fig. S4a–c) or anti-IL-33-treated mice (Fig. S4d–f) with schistosomiasis, or Il-33-/- mice with sepsis (Fig. S4g–i). This evidence concerns the gene IL33 and schistosomiasis.