In addition, sepsis, a severe systemic infectious disease, also resulted in increased IL-33 level in the thymus (Fig. S3g), and as a consequence, caused thymic involution in mice and humans (Fig. S3h–k), while IL-33 deficient mice displayed the normal morphology, weight, and cellularity of the thymus during sepsis (Fig. S3h–j). This evidence concerns the gene IL33 and Sepsis.