TRIM21 and interstitial lung disease: “V”-neck sign (OR = 0.07, 95%CI 0.02–0.28, P < 0.001) and “shawl” sign (OR = 0.22, 95%CI 0.06–0.79, P = 0.021) had an inverse association with anti-tRNA synthetases, while “mechanics’ hands” (OR = 5.30, 95%CI 1.49–18.90, P = 0.010), ILD (OR = 5.38, 95%CI 1.47–19.72, P = 0.011), and anti-Ro-52 antibodies (OR = 3.82, 95%CI 1.10–13.28, P = 0.035) had a positive association with anti-tRNA synthetases.