“Mechanics’ hands” (OR = 4.30, 95%CI 1.41–13.13, P = 0.011), arthritis (OR = 3.67, 95%CI 1.34–10.03, P = 0.011), RP-ILD (OR = 3.82, 95%CI 1.10–13.28, P = 0.035), anti-tRNA synthetases (OR = 3.82, 95%CI 1.10–13.28, P = 0.035), and anti-MDA-5 (OR = 5.53, 95%CI 1.29–23.68, P = 0.021) were associated with anti-Ro-52 antibodies (Table 5). Here, TRIM21 is linked to arthritic joint disease.