BRCA1 and ovarian serous adenocarcinoma: Whole exome sequencing combined with transcriptome profiling has found that alterations in at least one HRR gene were present in about 50% of high grade serous ovarian cancer where this may be mediated by RNA polymerase regulator CDK12, which is required for the transcription of key HRR-related genes such as BRCA1, ATR, FANCI, and FANCD2 [36].