For instance, the hypoxic metabolism of posterior fossa A ependymoma generates intermediary products that favor higher levels of H3K27ac (acetyl-CoA) and lower levels of H3K27me3 (α-ketoglutarate, which stimulates the activity of the H3K27 demethylases KDM6A and KDM6B)[65]. The gene discussed is KDM6A; the disease is ependymoma.