We selected these genes because (1) they displayed |Log2(fold change)| >0.2 in the Chronic Drinking group, (2) their transcripts are detected in mouse brain (Allen Brain Institute), and 3) some of genes including Bc1, Btg2, Nenf, and Nts have previously been shown to play roles in synaptic plasticity [37], neuronal proliferation [38], anxiety [39], and alcohol drinking [40], respectively. The gene discussed is NENF; the disease is Anxiety.