NFKB1 and cancer: However, the top scoring gene sets for TNFα (mRNA) produced a gene set representing cancer motility and invasion genes up-regulated by the AP-1 transcription factor (Ozanne_AP1_TARGETS_UP, Fig. 4C), and one representing TNF receptor superfamily (TNFSF) members mediating the non-canonical NF-kB pathway (REACTOME_TNF_RECEPTOR_SUPERFAMILY_TNFSF_MEMBERS_MEDIATING_NONCANONICAL_NF_KB_PATHWAY, Fig. 4D).