PRELP and urinary bladder carcinoma: Although H2BK5 acetylation was increased in the protein as a whole following SAHA treatment (Additional file 1: Fig. S2), our results indicate that repression of PRELP gene expression involves deacetylation of H2BK5ac in the promoter region, and SAHA treatment reverses the repression via H2BK5ac in bladder cancer cells.