To explore the effect of LSM2 expression on the prognosis of 33 types of cancer, univariate Cox regression analysis indicated that LSM2 overexpression was inversely correlated with poor OS in SKCM (p = 0.013), LIHC (p = 0.005), kidney renal clear cell carcinoma (KIRC) (p = 0.006), kidney renal papillary cell carcinoma (KIRP) (p = 0.005), OV (p = 0.024), rectum adenocarcinoma (READ) (p = 0.017), sarcoma (SARC) (p = 0.017), TGCT (p = 0.017), THYM (p = 0.013), uveal melanoma (UVM) (p = 0.003), and lung adenocarcinoma (p < 0.001). The gene discussed is LSM2; the disease is sarcoma.