This re-distribution of FZD7 seems to have (1) promoted the binding with Wnts, promoted the activation of the WNT pathway, (2) facilitated the entrance of β-catenin into the nucleus, (3) initiated the transcription of downstream target genes, and (4) ultimately promoted the proliferation, invasion, and metastasis of PC. This evidence concerns the gene FZD7 and pachyonychia congenita.