To detect the synergistic effects of ZNF416 siRNA-loaded liposomes and TGF-β signaling in vivo, we made another intervention model by administration of ZNF416 siRNA-loaded liposomes and TGF-β1 receptor inhibitor SB431542 in silica and BLM-induced pulmonary fibrosis (Fig. 8A and Additional file 1: Fig. S8A). The gene discussed is ZNF416; the disease is pulmonary fibrosis.