Further, SMARCA4 (BRG1) encodes a core catalytic component of the SWI/SNF complex and its inactivation is indicative of the presence of hypercalcemic-type small cell carcinoma of the ovary [15, 16], and loss-of-function (LOF) mutations of SMARCB1 (SNF5/INI1/BAF47), which encodes another core subunit of the SWI/SNF complex, have been identified in the majority of rhabdoid tumors [17, 18]. The gene discussed is SMARCA1; the disease is rhabdoid tumor.