Additionally, the DUF3518 domain of ARID1A was found to be functionally necessary to antagonize EZH2, and both the R1989* variant and the deletion of the DUF3518 domain could not rescue EZH2-mediated IFN-γ signaling gene repression in ARID1A-knockout ovarian cancer cells [66]. The gene discussed is EZH2; the disease is ovarian cancer.