Somatic mutations in SMARCA4 and/or BRG1 (Brahma-related gene 1) loss are present in a subset of non-small cell lung carcinomas with distinct morphological features, harboring less EGFR mutations, but more KRAS, STK11, and KEAP1 mutations [68, 69]. The gene discussed is SMARCA4; the disease is non-small cell lung carcinoma.