The SWI/SNF genes, ARID1A, ARID1B, ARID2, SMARCA4, SMARCB1, and PBRM1 were mutated in up to 21.8% of all the cancers, and SWI/SNF mutation carriers had significantly higher TMB values as well as higher TMB-H and MSI-H proportions than their SWI/SNF-non-mutant counterparts in several malignancies. Here, SMARCA4 is linked to cancer.