Of the top 20 mutated genes, excluding the six hub genes, it is well known that APC, KRAS, PIK3CA, EGFR, LRP1B, BRCA2, ATM, and ROS1 are mutated in several cancer types, such as non-small cell lung cancer, colorectal cancer, and endometrial cancer. The gene discussed is PIK3CA; the disease is endometrial cancer.