Of the top 20 mutated genes, excluding the six hub genes, it is well known that APC, KRAS, PIK3CA, EGFR, LRP1B, BRCA2, ATM, and ROS1 are mutated in several cancer types, such as non-small cell lung cancer, colorectal cancer, and endometrial cancer. Here, APC is linked to non-small cell lung carcinoma.