The proportions of patients who previously experienced non-ischemic cardiomyopathy (NIMD), pre-DM, NGR, hyperlipidemia, intake of angiotensin-converting enzyme inhibitor/angiotensin receptor inhibitor/ angiotensin receptor neprilysin inhibitor (ACEI/ARB/ARNI) were significantly lower in the MACCEs group. The gene discussed is ACE; the disease is nonischemic cardiomyopathy.