As shown in Supplementary Fig. 1, we found that TRPC1, TRPM2, TRPM4, MCOLN1, PDK2, TRPV2 and TRPV4 were highly expressed in PAAD tissues, while MCOLN3 and TRPV6 were lowly expressed. Here, MCOLN1 is linked to pancreatic adenocarcinoma.