As shown in Supplementary Fig. 1, we found that TRPC1, TRPM2, TRPM4, MCOLN1, PDK2, TRPV2 and TRPV4 were highly expressed in PAAD tissues, while MCOLN3 and TRPV6 were lowly expressed. The gene discussed is TRPV6; the disease is pancreatic adenocarcinoma.