To clarify the nature of the bilateral adrenal tumors, comprehensive adrenal hormone tests were performed, including serum cortisol, adrenocorticotropic hormone (ACTH), 1 mg overnight dexamethasone suppression test (ODST), dehydroepiandrosterone (DHEA), and 24-h urine vanillylmandelic acid (VMA) and catecholamines. The gene discussed is POMC; the disease is adrenal gland neoplasm.