MLH1 and Lynch syndrome: Lynch syndrome–related PGVs were identified in 1,945 (5.7%) individuals; 477 (1.4%) carried a PGV variant in MLH1, 537 (1.6%) in MSH2, 513 (1.5%) in MSH6, 381 (1.1%) in PMS2, and 37 (0.1%) in EPCAM (Fig 1, Data Supplement).