In vitro experimental evidence additionally suggests a beneficial role for reduced IL-10 signaling in diseases including Filariasis (Brugia malayi), Capillariasis intestinal (Capillaria philippinensis), Opisthorchiasis (Opisthorchis felineaus) Clonorchiasis (Clonorchis sinensis), and Echinostomiasis (Echinostoma caproni) [44–55] (Fig. 6C). The gene discussed is IL10; the disease is filariasis.