Importantly, geospatial analyses of age and gender-adjusted prevalence rates of IBD by the Global Burden of Disease 2017 Inflammatory Bowel Disease Collaborators [43] have not revealed an enrichment in East Asia, suggesting that IBD per se is not of high prevalence in the East Asian region although it has been increasing over the previous decades, but the monogenic condition IL10RA-associated infantile enterocolitis has highest absolute case numbers reported worldwide in the East Asian region (China, Japan and South Korea). Here, IL10RA is linked to inflammatory bowel disease.