While the two variants in IL10 that have been identified in patients with infantile-onset IBD are both non-synonymous variants, the sequence length-normalized proportions of non-sense LOF variants and confirmed splice variants in IL10RB and IL10RA are 2.5% and 1.8%, and 1.6% and 1.7%, respectively (Fig. 1B). Here, IL10RB is linked to inflammatory bowel disease.