Among the 207 reported patients with infantile IBD caused by IL-10 signaling pathway defects, the majority present with IL10RA deficiency (n = 175; 84.5%), followed by IL10RB (n = 27; 13.0%), and IL10 defects (n = 5; 2.5%) [23] (Fig. 1A; Table S1; Table S2). The gene discussed is IL10RB; the disease is inflammatory bowel disease.