SKI and cardiomyopathy: In the literature from 22 to 27% (Table 1) of patients (Battaglia et al., 2008; Shimada et al., 2015) presented cardiomyopathy and two critical regions for cardiomyopathy have been described one of which includes PRKCZ, SKI, and PRDM16 (Zaveri et al., 2014).