In the literature from 22 to 27% (Table 1) of patients (Battaglia et al., 2008; Shimada et al., 2015) presented cardiomyopathy and two critical regions for cardiomyopathy have been described one of which includes PRKCZ, SKI, and PRDM16 (Zaveri et al., 2014). Here, PRDM16 is linked to cardiomyopathy.