This suggests either a positional effect, indeed, deletions may be responsible for Topologically Associating Domains (TADs) disruption and chromatin disorganization leading to the deregulation of several genes or candidate genes for microcephaly as CDC42 (Takenouchi et al., 2016), SKI, or RERE (Figures 4 and S1). This evidence concerns the gene SKI and microcephaly.