SPEN and neurodevelopmental disorder: The gene SPEN (chr1:15.8–15.9(hg18), 16.1–16.2(hg19)) recently published as causing neurodevelopmental disorder (Radio et al., 2021) was deleted in only two patients in our cohort (del68 and del54) both sharing deletion of long segments (including MOR3 or MOR4, respectively).