In leukemia cells grown in vitro, treatment with HB evidently induces the TNFα [26] regulated pro‐apoptotic cascade, whilst in PBMC a pro‐inflammatory process is induced with notable association of anti‐apoptotic factors (c‐FLIP, caspase‐8 and ‐10), which forms the apoptosis inhibitory complex (AIC). Here, TNF is linked to leukemia.