Studies of apoptosis induction in other tumor cell types suggest the possibility of Bax/Bak‐independent apoptosis induction with TRAIL agonists, which bind to the tumor cell surface [37] and may lead to a tumor cell sensitization by ROS generation and mitochondrial depolarization as a way to override anti‐apoptotic mechanisms that are upstream of the mitochondrial apoptosis cascade. This evidence concerns the gene BAK1 and neoplasm.