In this work, we showed that HB, especially at a concentration of 0.2 mg·mL−1, initiates a process of tumor cells sensitization to pro‐apoptotic activation, probably via the Bax/Bak‐independent mitochondrial depolarization by ROS generation and TRAIL‐like activation, followed by inhibition of NFκB signaling pathway. The gene discussed is BAX; the disease is neoplasm.