An earlier study has shown the positive association between the Allobaculum and the expression of angiogenin-like protein 4 (ANGPTL4), which has a crucial role in lipid deposition by repressing the lipoprotein lipase (LPL) enzyme and developing the pathophysiology of the obesity-related metabolic disorder50. This evidence concerns the gene ANGPTL4 and obesity due to melanocortin 4 receptor deficiency.