In the Wellness After Breast Cancer-II (WABC-II) cohort, which comprised post-menopausal women with stage I-III BC (ER+ and/or HER2+), the presence of a high-risk IL-6 promoter genotype (−174G/G or −597G/G, frequency 58%) conferred an increased risk for breast cancer relapse among the ER+ subjects (odds ratio 2.35 [95% CI 1.16–4.77, p = 0.018])7. Here, ESR1 is linked to breast carcinoma.