Preclinical work has shown that IL-6/STAT3 signaling takes control of a subset of shared IL-6/ER-enhancers to both drive BC invasion and render the BC resistant to ET, and that this process can be inhibited through blockade of IL-6/STAT3 with ruxolitinib, an oral JAK1/2 inhibitor11. The gene discussed is JAK1; the disease is breast cancer.