The exceptional BBB penetration as well as tumor accumulation of ARNGs@TMZ/ICG were mainly attributed to the receptor-mediated transcytosis, in that LDL receptor family was overexpressed by both endothelial cells of BBB and U87MG brain tumor cells (Supplementary Fig. 7), which had a strong binding affinity with ApoE peptide (Fig. 5e). The gene discussed is LDLR; the disease is neoplasm.