Met–aromatic interactions are associated with several age-associated diseases, including Alzheimer's, Creutzfeldt–Jacob, and von Willebrand diseases, as well as NleB/SseK-relevant TNF ligand-receptor complexes, namely TRAIL-DR5 and LT-TNFR1. Here, TNFRSF1A is linked to platelet-type von Willebrand disease.