INSR and autism: As shown in Table 1 (and in more detail in Supplementary Data 16), this meta-locus is uniquely characterized by genes associated with carbohydrate metabolism and response to lipid, including the insulin receptor gene INSR. This finding is consistent with recent GWAS evidence indicating that anorexia is (in significant part) a metabolic disorder50, and extends this finding to demonstrate pleiotropy of this result with cognitive performance and autism.