To test whether increased stromal Foxf2 in the lung can affect lung colonization of metastatic prostate cancer cells, we injected RM-1 cells expressing the firefly luciferase and GFP through tail veins into the tamoxifen-treated Col1a2-CreERT2;R26-LSL-Foxf2Tg/Tg (Col1a2-Foxf2) and Col1a2-CreERT2 control mice. Here, COL1A2 is linked to Familial prostate cancer.