DNM2 and centronuclear myopathy: Altogether, these molecular data support the Ub-DNM2 isoform is the main contributors of CNM pathogenesis as it is more sensitive to the CNM mutation, and this is in agreement with our in vivo data showing Ub-DNM2 overexpression in a WT and CNM (Mtm1−/y) context has a more pathological impact than M-DNM2.