Another locus on chr.5q11.2 (rs6859219, Beta = 0.07, P = 1.41 × 10−20) encoding ANKRD55 (closest gene) and IL6ST has previously been associated with IgA levels20, IgG glycosylation50 and increased risk of multiple sclerosis, rheumatoid arthritis, and Crohn’s disease (Fig. 1c, Supplementary Data 2). This evidence concerns the gene IL6ST and Crohn disease.