This study showed that nilotinib was associated with reduced amyloid burden in the frontal lobes measured with amyloid positron emission tomography (Florbetaben PET), attenuated hippocampal atrophy on MRI and reduced CSF amyloid beta (Aβ) 40 and 42 and CSF phosphorylated tau 181; however, it was underpowered to detect any cognitive or clinical benefits [53]. The gene discussed is MAPT; the disease is hippocampal atrophy.