In non-small cell lung cancer (NSCLC) cell lines, the expression of E-cadherin, EpCAM and αvβ6 was found to induce the transcription of TGF-β1 and TGF-βR1 in normal fibroblasts to modulate tumor progression and therapeutic responsiveness [59]. The gene discussed is TGFBR1; the disease is non-small cell lung carcinoma.