We determined CMV infection by the presence of CMV IgG in serum and found that the frequency of CMV-specific CD8+ T cells were significantly increased (14.5 ± 8.1-fold, Mean ± SEM) in CMV IgG positive subjects than in CMV IgG negative subjects (Fig. 1B, Supplemental Table S1). The gene discussed is CD8A; the disease is cytomegalovirus infection.