SFRP1 and intrahepatic cholangiocarcinoma: The CpG island in the promoter of SFRP1 is hypermethylated in ICC tissues, according to the methylation data in GSE38860 and GSE49656 (Fig. S3A, B) BSP indicated that the percentages of methylated CpG in HuccT-1 and RBE cells transduced with LV-shR-NC and blank control cells were significantly lower than that in LV-shR-H2A.Z-transduced cells, while no difference was found in HIBEpic cells (Fig. 4C).