To understand the regulatory role of H2A.Z in SFRP1 expression, we characterized the relative levels of H2A.Z expression in ICC and nontumor HIBEpic cells and found that the levels of H2A.Z expression in ICC cells was significantly higher than that in nontumor HIBEpic cells. Here, SFRP1 is linked to intrahepatic cholangiocarcinoma.