SFRP1 and intrahepatic cholangiocarcinoma: In this study, we identified a new mechanism by which H2A.Z inhibits SFRP1 expression by forming a complex with KDM1A in the nucleus of ICC cells through binding to the -151 ~ -136 bp region of upstream and demethylating the SFRP1 promoter, thus promoting tumorigenesis in the context of ICC.