We first found that SFRP1 and H2A.Z were expressed predominantly in the nucleus in cells in ICC tissues and that downregulated SFRP1 expression was associated with upregulated H2A.Z expression in ICC tissues and was also associated with pathological grade, lymph node metastasis and distant metastasis. The gene discussed is SFRP1; the disease is intrahepatic cholangiocarcinoma.