Some previous studies have demonstrated that H2A.Z was shown to interact with components of complexes involved in a multitude of biological processes, such as DNA damage repair [26], gene activation [27], gene repression [28], various transcription factors [29–31], and chromatin remodeling [32]; however, the underlying mechanism of action remains unclear in ICC. This evidence concerns the gene H2AZ1 and intrahepatic cholangiocarcinoma.